Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus.

Complex formation processes of tetrasulfosubstituted cobalt(II) phthalocyanine with ORF3a accessory protein of SARS-CoV-2 coronavirus were studied. The interaction of ORF3a protein with SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine affords a stable complex in which metallophthalocyanine exists in the monomeric form. The complex formation induces slight changes in the secondary structure of the protein by increasing the fraction of disordered fragments of the polypeptide chain.

[The maturation steps of human immunodeficiency virus and the role of proteolysis].

HIV-1 virions are as immature noninfectious particles lacking a central core. Shortly after budding, virions temporally mature and acquire cores and infectious activity. The cause of maturation remains poorly studied.

[Analysis of the genome of two Getah virus strains (LEIV 16275 Mar and LEIV 17741 MPR) isolated from mosquitoes in the North-Eastern Asia].

The complete nucleotide consequences of two Getah virus strains isolated in Russia (LEIV 16275 Mar) and Mongolia (LEIV 17741 MPR) were first determined and analyzed. The nucleotide sequences of the gene of surface glycoprotein E2 and complete genome were used to establish the phylogenetic relations of the strains with other representatives of the Semliki forest serocomplex. The study and reference strains of Getah virus were shown to form its own cluster that was far away from other representatives of the complex and the sequence of the E2 gene significantly reflected the identification of phylogenetical groups within the Sempliki forest serocomplex.

[Molecular genetic analysis of a diversity of Getah virus strains isolated from mosquitoes in the North-Eastern Asia].

A molecular genetic study was performed of the Getah virus strains isolated in Russia (Eastern Siberia and Far East) and Mongolia. A phylogenetic analysis was made, by examining the nucleotide sequences of genome fragments that had been obtained by RT-PCR and that included the portions of the E1 and E2 surface glycoprotein genes and the 6K gene. A genetic diversity of Getah virus strains in North-Eastern Asia is discussed.

[Complex environmental and virological monitoring in the Primorye Territory in 2003-2006].

The paper presents the results of monitoring of viruses of Western Nile (WN), Japanese encephalitis (JE), tick-borne encephalitis (TBE), Geta, Influenza A, as well as avian paramicroviruses type I (virus of Newcastle disease (ND)) and type 6 (APMV-6) in the Primorye Territory in 2003-2006. Totally throughout the period, specific antibodies to the viruses were detected by neutralization test in wild birds (7.3%, WN; 8.