Publications by authors named "E N Graf"
Metagenomic sequencing of plasma has been advertised by Karius, Inc. as a way to diagnose a variety of infectious syndromes. Due to the lack of robust evidence of clinical utility, our laboratory began actively stewarding Karius testing.
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- The text discusses the rapid development of Large Language Models (LLMs) like OpenAI's GPT and their increasing importance in fields such as science and medicine, yet highlights the need for evaluating their quality and effectiveness in statistical applications.
- The project's objective is to explore the utility and satisfaction of LLMs in statistical consulting by creating and assessing a training module, while identifying strengths and areas for improvement.
- The study employs a multimodal approach, incorporating both qualitative and quantitative methods across four parts to gather insights on using LLMs in consulting, evaluating training effectiveness, and understanding staff experiences and attitudes at the Medical Center and University of Freiburg.
Positive impact of a diagnostic stewardship intervention on syndromic panel ordering practices and inappropriate treatment.
Infect Control Hosp Epidemiol
November 2024
Objective: Multiplex polymerase chain reaction (PCR) panels for stool testing may be used to diagnose , which can circumvent more appropriate targeted testing, resulting in treatment of incidentally detected colonization. We sought to reduce diagnosis via a gastrointestinal pathogen panel (GIPP).
Design: Quasi-experimental, pre/post, retrospective cohort study from January 1, 2022, to January 31, 2024.
Background: Exome sequencing has been established as a fundamental tool in genetic diagnostics. It may also provide information about variants in genes unrelated to the primary purpose, so-called secondary findings. Especially, diagnoses of unnoticed inborn cardiac diseases are of high clinical relevance due to therapeutic options in context of prevention of sudden cardiac death.
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