[Algorithm for examination of bone marrow trephine biopsy specimens in myelodysplastic syndromes].

Based on the analysis of more than 1000 bone marrow trephine biopsy specimens from patients with myelodysplastic syndromes before starting any specific therapy, the authors propose histological criteria for their evaluation (an examination algorithm), an optimal panel of immunohistochemical examination, and histological criteria for predicting the course of the disease.

[Morphological evaluation of dysmyelopoiesis in decitabine-treated patients with myelodysplastic syndromes].

Aim: To estimate a change in myelodysplasia in decitabine-treated patients with myelodysplastic syndromes (MDS).

Subjects And Methods: Thirteen MDS patients from a high-risk group were examined; 75 bone marrow puncture specimens and 67 bone marrow trepanobiopsy specimens from these patients were analyzed before and after decitabine treatment. Dysplastic changes in the hematopoietic cells were monitored during the treatment.

[Crystalline histiocytosis].

The paper describes a case of diagnosis of the rare monoclonal secretion-associated disease crystalline histiocytosis with kidney and bone marrow involvement. The female patient with multiple myeloma (MM) was found to have intralysosomal crystals in the cells of the bone marrow (histiocytes, plasmocytes), kidneys proper (mesangiocytes, podocytes), and subsequently in those of a kidney graft. Lower secreted monoclonal IgG and ceased Bence-Jones protein secretion after MM chemotherapy were accompanied by improved and stabilized kidney graft function.