NR1D1 Inhibition Enhances Autophagy and Mitophagy in Alzheimer's Disease Models.

Alzheimer's disease (AD) is marked by extracellular beta-amyloid (Aβ) plaques and intracellular Tau tangles, leading to progressive cognitive decline and neuronal dysfunction. Impaired autophagy, a process by which a cell breaks down and destroys damaged or abnormal proteins and other substances, contributes to AD progression. This study investigated Nuclear Receptor Subfamily 1 Group D Member 1 (NR1D1) as a potential therapeutic target for modulating autophagy.

Open-ended urethral catheters reduce catheter obstruction after hypospadias repair.

Backgrounds: Urethral catheter obstruction is a notable issue that pediatric patients with hypospadias may encounter in the early postoperative period. This retrospective study aims to assess the efficacy of open-ended urethral catheters with 2 side holes in mitigating catheter obstruction in pediatric patients following hypospadias repair.

Materials And Methods: The clinical data of pediatric patients who underwent hypospadias repair surgery from January 2021 to October 2023 were retrospectively collected.

An influenza mRNA vaccine protects ferrets from lethal infection with highly pathogenic avian influenza A(H5N1) virus.

The global spread of the highly pathogenic avian influenza (HPAI) A(H5N1) virus poses a serious pandemic threat, necessitating the swift development of effective vaccines. The success of messenger RNA (mRNA) vaccine technology in the COVID-19 pandemic, marked by its rapid development and scalability, demonstrates its potential for addressing other infectious threats, such as HPAI A(H5N1). We therefore evaluated mRNA vaccine candidates targeting panzootic influenza A(H5) clade 2.

NAD Boosting Strategies.

Nicotinamide adenine dinucleotide (oxidized form, NAD) serves as a co-substrate and co-enzyme in cells to execute its key roles in cell signalling pathways and energetic metabolism, arbitrating cell survival and death. It was discovered in 1906 by Arthur Harden and William John Young in yeast extract which could accelerate alcohol fermentation. NAD acts as an electron acceptor and cofactor throughout the processes of glycolysis, Tricarboxylic Acid Cycle (TCA), β oxidation, and oxidative phosphorylation (OXPHOS).

Cationic polymerization of vinyl ethers using trifluoromethyl sulfonate/solvent/ligand to access well-controlled poly(vinyl ether)s.

Cationic polymerization of vinyl ethers to access poly(vinyl ether) polymeric materials has been challenging due to stringent polymerization conditions and inevitable chain transfer. Herein we introduce a protocol using trifluoromethyl sulfonates to catalyze the polymerization of a series of vinyl ethers. These trifluoromethyl sulfonates are fully commercially available and can be stored under ambient conditions.