[COVID-19 in haemodialysis patients: result analysis of the first year of the pandemic].

Background: Present concepts of the novel coronavirus infection prognosis in haemodialysis (HD) patients are rather controversial. There is little information on therapy efficiency and safety in such patients. We studied COVID-19 course specifics, prognostic factors associated with fatal outcomes, therapy efficiency and its transformation at different stages of the pandemic first year.

[Influence of nanosize particles of cobalt ferrite on contractile responses of smooth muscle segment of airways].

Contractile responses of airways segments of porpoises inhaling nanopowder CoFe2O4 were stidued by means of a mechanographic method. Inhalation of the nanosize particles of CoFe2O4 in vivo and in vitro testing the nanomaterial on isolated smooth muscles led to potentiation histaminergic, cholinergic contractile activity in airways of porpoises and to strengthening of adrenergic relaxing answers. Nanosize particles vary amplitude of hyperpotassium reductions in smooth muscle segments of airways similarly to the effect of depolymerizing drug colchicine.

[Clinical variants of chronic urticaria associated with Helicobacter pylori].

Introduction: Chronic urticaria (CU) is one of the toughest problems. The main difficulty is the search for an etiological factor in 70-90% of cases the cause of chronic urticaria remains unclear. In the development and persistence of CU recently paid great importance to the role of Helicobacter pylori infection (HP), which is the most common bacterial infection in humans.

[Definition of parameters of the condition of oxidizing stress in smooth muscle cells under influence of exogenous nitroso-glutatyon in vitro].

Influence of exogenous nitroso-glutatyon on intensity of oxidizing processes in smooth muscles of colon and bronchial tubes in intact and atopic sensitised porpoises (guinea pigs) was studied. In sensitised porpoises, antioxidant protection has been initially reduced against the background of increased maintenance of products of oxidizing that reflects a picture of oxidizing damage and can be associated with an inflammatory process. In incubation with nitroso-glutatyon, a decrease in activities of syperoxiddismutase and catalase is marked and, in sensitised animals, this effect has been expressed to a lesser degree.

[Features of the pharmacosensitivity of smooth muscles of the lesser circulation circle artery walls in rabbits].

Features of the pharmacological sensitivity of smooth muscles in the walls of arteries of the lesser circulation circle in rabbits with respect to cholinergic, histaminergic, and adrenergic agents, as well as the influence of endothelium on the realization of contractile response to these agents have been investigated in rabbits. A special feature in the cholinergic relaxation of smooth muscles of a pulmonary artery is a two-componential character of the dose dependence. The low-threshold component of the relaxant action of pilocarpine exhibits the endothelium-dependent character.