Specifics of Pharmacokinetics and Biodistribution of 5-Fluorouracil Polymeric Complex.

Unlabelled: One of the promising and relevant directions in the treatment of oncological diseases is currently the development of a system for the delivery of antitumor drugs based on polyanions. Therefore, the aim of this work was to study the specifics of pharmacokinetics and biodistribution of a 5-Fluorouracil polymeric complex compared with commercial 5-Fluorouracil.

Materials And Methods: Monomeric methacrylic acid was used to synthesize polymers; 2-phenylpropane-2-ilbenzodithioate was used for the synthesis of poly(methacrylic acid).

Effect of Poly(methacrylic acid) on the Cytokine Level in an In Vivo Tumor Model.

Unlabelled: Cancer is a leading cause of mortality globally. Despite remarkable improvements in cancer-treatment approaches, disease recurrence and progression remain major obstacles to therapy. While chemotherapy is still a first-line treatment for a variety of cancers, the focus has shifted to the development and application of new approaches to therapy.

Wideband MOEMS for the Calibration of Optical Readout Systems.

The paper proposes a technology based on UV-LIGA process for microoptoelectromechanical systems (MOEMS) manufacturing. We used the original combination of materials and technological steps, in which any of the materials does not enter chemical reactions with each other, while all of them are weakly sensitive to the effects of oxygen plasma. This made it suitable for long-term etching in the oxygen plasma at low discharge power with the complete preservation of the original geometry, including small parts.

Transport properties of nitrile and carbonate solutions of [P66614][NTf] ionic liquid, its thermal degradation and non-isothermal kinetics of decomposition.

The electrical conductivity, density and diffusion coefficients of trihexyl(tetradecyl)phosphonium bis(trifluoromethylsulfonyl)amide ([P66614][NTf]) ionic liquid and its binary solutions in acetonitrile, propionitrile, dimethyl and diethyl carbonates were measured in the temperature range of 293-348 K. The electrical conductivity - ionic liquid mole fraction dependencies for the binary solutions were fitted with the empirical Casteel-Amis equation. The temperature dependencies of electrical conductivity were analyzed using the Arrhenius, Litovitz and Vogel-Fulcher-Tammann approaches.

Immunopharmacological Properties of Methacrylic Acid Polymers as Potential Polymeric Carrier Constituents of Anticancer Drugs.

Cytostatic chemotherapeutics provide a classical means to treat cancer, but conventional treatments have not increased in efficacy in the past years, warranting a search for new approaches to therapy. The aim of the study was, therefore, to obtain methacrylic acid (MAA) (co)polymers and to study their immunopharmacological properties. 4-Cyano-4-[(dodecylsulfanylthiocarbonyl)sulfanyl] pentanoic acid (CDSPA) and 2-cyano-2-propyl dodecyl trithiocarbonate (CPDT) were used as reversible chain transfer agents.