Immunisation of goats against contagious caprine pleuropneumonia using sonicated antigens of F-38 strain of mycoplasma.

Three groups of 15 goats each were immunised against contagious caprine pleuropneumonia (CCPP) using sonicated antigens of the F-38 strain of mycoplasma incorporated in incomplete Freund's adjuvant (IFA), emulsified in aluminium hydroxide and phosphate buffered saline respectively. Three months after immunisation, five goats from each group were challenged by the in-contact method. The goats immunised with the antigen incorporated in IFA were all solidly immune to the challenge whereas only two of five of the goats in the other two groups were protected.

Passive haemagglutination and complement fixation as diagnostic tests for contagious caprine pleuropneumonia caused by the F-38 strain of mycoplasma.

Passive haemagglutination and complement fixation tests were used to assess the antibody response of goats to the F-38 strain of mycoplasma. The passive haemagglutination test was found to have a positive correlation (r:0.89) with the complement fixation test in detection of antibody to strain F-38.

Treatment of contagious caprine pleuropneumonia.

A combination of dihydrostreptomycin sulphate (250 mg/ml) and penicillin G procaine (200,000 iu/ml) was used to treat contagious caprine pleuropneumonia caused by F38 strain of mycoplasma. A single dose of either 20, 30, 40 or 50 mg/kg body weight of the dihydrostreptomycin sulphate led to the recovery of the treated goats. The recovered goats did not transmit CCPP to susceptible goats housed with them for 2 months.