Prostate cancer cells of increasing metastatic potential exhibit diverse contractile forces, cell stiffness, and motility in a microenvironment stiffness-dependent manner.

During metastasis, all cancer types must migrate through crowded multicellular environments. Simultaneously, cancers appear to change their biophysical properties. Indeed, cell softening and increased contractility are emerging as seemingly ubiquitous biomarkers of metastatic progression which may facilitate metastasis.

Best behaviour: A proposal for a non-binary conceptualization of behaviour in biology.

Behaviour is a widespread object of research in biology, yet it is often left undefined, and the variety of existing definitions have not led to a consensus. We argue that the fundamental problem in defining behaviour has been the assumption that the concept must be categorical: either a phenomenon is a behaviour or it is not. We propose instead that 'behaviour' is best understood as a spectrum concept.