Publications by authors named "E Mundt"
In the human and veterinary fields, oral vaccines generate considerable interest. In dogs, these vaccines are newly developed, and understanding their mechanisms is crucial. Mesenteric lymph nodes (MLNs) and Peyer's patches (PPs) are important sites for gastrointestinal mucosal induction, yet canine MLNs lack sufficient information.
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- Oral vaccination is effective for stimulating immune responses, with GALT and Peyer's patches being key players; however, our knowledge about these systems in dogs is still limited.
- The research involved advanced techniques like immunofluorescence, flow cytometry, and single-cell RNA sequencing to study canine Peyer's patches and their immune cell populations.
- The development of a specific antibody targeting canine M cells will assist in understanding how antigens enter the dog's GALT, providing insights for future studies on dog immune responses and diseases.
Background And Aims: Heterozygous truncating pathogenic variants (PVs) in CHEK2 confer a 1.5 to 3-fold increased risk for breast cancer and may elevate colorectal cancer risks. Less is known regarding missense variants.
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