Publications by authors named "E Moscoso"
Recent research suggests that a polygeneric immunogen made from the venoms of the most medically important viperid and elapid snakes in sub-Saharan Africa could elicit a broader antibody response in horses compared to the current EchiTAb-plus-ICP antivenom, especially against neurotoxic elapid venoms. To test this, 25 horses that have been regularly immunized to produce this antivenom were reimmunized with an immunogen containing 22 venoms from various snake species from the genera , , , and both spitting and non-spitting . The plasma collected from these horses was processed using the caprylic acid method to produce an industrial-scale freeze-dried antivenom.
View Article and Find Full Text PDFThe immunization and industrial bleeding of horses are essential stages for producing snake antivenoms. In Costa Rica, the traditional method involves stimulating the antibody response of horses by periodically injecting venoms, collecting hyperimmune plasma over three consecutive bleeding days, and repeating this process every eight weeks. While this method does not cause major physical or hematological issues in horses, the associated stress has not been evaluated.
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- Snakebite is a significant public health issue in the MENA region, but the extent of the problem is not well understood, and existing antivenoms are often not suitable across different areas.
- Researchers developed a new antivenom called MENAVip-ICP, created from the plasma of horses that were immunized with various viper venoms from MENA, aiming to provide a more effective and regionally applicable treatment.
- The new antivenom demonstrated improved effectiveness, particularly through intraperitoneal administration, and showed promise in neutralizing venoms from other geographical regions not included in its initial development.
Temporary Target Versus Suspended Insulin Infusion in Patients with Type 1 Diabetes Using the MiniMed 780G Advanced Closed-Loop Hybrid System During Aerobic Exercise: A Randomized Crossover Clinical Trial.
Diabetes Technol Ther
November 2024
To compare the safety in terms of hypoglycemic events and continuous glucose monitoring (CGM) metrics during aerobic exercise (AE) of using temporary target (TT) versus suspension of insulin infusion (SII) in adults with type 1 diabetes (T1D) using advanced hybrid closed-loop systems. This was a randomized crossover clinical trial. Two moderate-intensity AE sessions were performed, one with TT and one with SII.
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- * Researchers compared different types of antiserum produced by immunizing horses with various snake venoms and found that polyspecific antiserum was the most effective at neutralizing venom from multiple species.
- * The findings support the use of polyspecific immunogens to create antivenoms that can provide broader protection against bites from snakes like Bitis, Echis, and non-spitting Naja in the region.