Publications by authors named "E Mordechai"
Bacillus Calmette-Guerin (BCG) is the current standard of care for non-muscle invasive bladder cancer (NMIBC), but recurrence is common. Additional therapeutic options are a major unmet medical need for treating unresponsive patients. Stimulator of Interferon Genes (STING) plays a central role in mounting innate and adaptive immune responses to tumor cells, and activation of STING is a promising immunotherapeutic approach.
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- A new qPCR test has been developed to identify 22 bacterial species linked to bacterial vaginosis (BV), addressing the limitations of current tests that focus on only a few species.
- The test was applied to 946 stored vaginal samples and showed 95-100% sensitivity and specificity, accurately classifying samples as BV-positive, BV-negative, or transitional BV within 8 hours.
- Findings revealed varying abundances of specific species among the samples and highlighted that while BV status fluctuated across different demographics, differences were statistically insignificant.
Development and Diagnostic Potential of a Novel Bartonella henselae-Specific Immunoglobulin.
Diagn Microbiol Infect Dis
September 2024
Bartonella henselae is a gram-negative rod-shaped bacterium and is the primary causative agent of Cat Scratch Disease (CSD). Although the prevalence of CSD is low in the human population, the possibility of developing multi-organ complications, especially in vulnerable individuals, remains a serious cause for concern. The immunofluorescent assay (IFA) is currently one of the most common laboratory tests for the detection of antibodies to B.
View Article and Find Full Text PDFHigh-Risk HPV Genotype Distribution According to Cervical Cytology and Age.
Open Forum Infect Dis
November 2022
Background: A retrospective study of a single laboratory's results from patients in the United States to investigate high-risk human papillomavirus (HPV) genotype distribution according to cervical cytology and age was performed.
Methods: Anonymous results of 23 580 patients' cervical specimens sent to Medical Diagnostic Laboratories, LLC, for cervical cytology and HPV testing between August 2020 and August 2021 were analyzed.
Results: Overall, any of the 14 high-risk HPV genotypes identified were detected in 2302 of the 23 580 patients (9.
Background: Trichomonas vaginalis is the most common nonviral sexually transmitted infection. However, because it is not a reportable disease in the United States, there is limited information on the age of infected individuals and their geographic distribution.
Objective: The purpose of this study was to evaluate the detection rates of T vaginalis infection compared with Chlamydia trachomatis by age and state in a commercial laboratory setting.