Publications by authors named "E Moran Pascual"
Objective: To describe the inflammatory profile of asymptomatic hyperuricemia (AH) with ultrasound evidence of monosodium urate (MSU) crystals (AH-MSUpos), vs AH without deposits (AH-MSUneg), intercritical gout, and normouricemia.
Methods: Based on serum urate levels, musculoskeletal ultrasound, and history of flares, we divided 122 participants into four groups: normouricemia, AH-MSUneg, AH-MSUpos, and intercritical gout. We tested four ultrasound definitions for MSU deposition in AH: grade 2-3 (G2-3) double contour and/or tophi, G1-3 double contour and/or tophi, G1-3 Stewart scheme (double contour sign in knee cartilage and/or first metatarsophalangeal joint and/or tophi in first metatarsophalangeal joint), and G2-3 Stewart scheme.
Objective: To estimate the prevalence and cumulative incidence of neuro-retinal-disorders (NRD) in HIV-controllers.
Design: Prospective, single-centre, cohort study of people living with HIV (PLWH): elite-controllers, long-term-non-progressors and early diagnosed.
Methods: The study compared "HIV-controllers" (including elite-controllers and long-term-non-progressors), who were not on antiretroviral therapy (ART), and "HIV-treatment" (HIV-infected subjects with a recent diagnosis and on ART).
Crystallization of monosodium urate monohydrate (MSU) leads to painful gouty arthritis. Despite extensive research it is still unknown how this pathological biomineralization occurs, which hampers its prevention. Here we show how inflammatory MSU crystals form after a non-inflammatory amorphous precursor (AMSU) that nucleates heterogeneously on collagen fibrils from damaged articular cartilage of gout patients.
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- The study aimed to identify a sonographic protocol for assessing urate crystal deposits in patients with asymptomatic hyperuricemia (AH) and determine how different definitions affect deposition rates and related features.
- A total of 77 participants were evaluated using ultrasound across 10 locations to identify different types of urate deposits and their associated inflammation and erosions.
- Results showed a wide range in deposition rates depending on the protocols used, emphasizing the need for a standardized definition to better understand and manage AH.
Article Synopsis
- - Serological tests are crucial for detecting autoantibodies (autoAbs) in autoimmune neuropathies (AN) and myasthenia gravis (MG), serving as biomarkers for diagnosis and treatment.
- - A comparison of autoAb testing across 27 Spanish diagnostic laboratories revealed significant variability in results, with particularly low sensitivity for anti-ganglioside and anti-MAG autoAb detection.
- - The study emphasizes the urgent need for standardization in autoAbs testing to improve reliability and accuracy in clinical applications for AN and MG.