Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness.

Introduction: Despite continued improvement in post-sepsis survival, long term morbidity and mortality remain high. Chronic critical illness (CCI), defined as persistent inflammation and organ injury requiring prolonged intensive care, is a harbinger of poor long-term outcomes in sepsis survivors. Current dogma states that sepsis survivors are immunosuppressed, particularly in CCI.

Postnatal Zika and Dengue Infection and their Effects on Neurodevelopment Among Children Living in Rural Guatemala.

Background: Prenatal Zika virus (ZIKV) infection leads to microcephaly and adverse neurodevelopment. The effects of postnatal ZIKV infection on the developing brain are unknown. We assessed the neurodevelopmental outcomes of children exposed postnatally during the ZIKV epidemic.

Surviving septic patients endotyped with a functional assay demonstrate active immune responses.

Introduction: Sepsis is a complex clinical syndrome characterized by a heterogenous host immune response. Historically, static protein and transcriptomic metrics have been employed to describe the underlying biology. Here, we tested the hypothesis that functional TNF expression as well as an immunologic endotype based on both IFNγ and TNF expression could be used to model clinical outcomes in sepsis patients.

Double emulsion microencapsulation of ionic liquids for carbon capture.

Microencapsulation of pristine core liquids in polymer shells has critical applications in thermal energy storage and management, targeted drug delivery, and carbon capture, among others. Herein, we report a novel encapsulation approach based on a double emulsion soft-template to produce microcapsules comprised of an ionic liquid (IL) core in a degradable polymer shell. We demonstrate the production of [IL-in-oil]-in-oil (IL/O/O) double emulsions, in which the oil interphase (O) contains a CO-derived polycarbonate bearing vinyl pendant groups, tetrathiol small molecule crosslinker, and photoinitiator; upon irradiation of the double emulsion under low shear, thiol-ene crosslinking of the loaded species results in the formation of a robust shell around the pure IL droplets.