Publications by authors named "E Monchatre-Leroy"
Article Synopsis
- The study investigated the presence of SARS-CoV-2 in four French mink farms during late 2020, amidst concerns of forming a new viral reservoir due to the COVID-19 pandemic.
- On one farm, a high percentage (96.6%) of serum samples tested positive, indicating significant circulation of the virus, with genetic analysis showing several variants cocirculating.
- Other farms showed lower seroprevalence but were positive for an alphacoronavirus, suggesting potential viral recombination, which may explain varied clinical symptoms across infected farms in Europe.
Spike-based COVID-19 vaccines induce potent neutralizing antibodies but their efficacy against SARS-CoV-2 variants decreases. OVX033 is a recombinant protein composed of the full-length nucleocapsid (N) protein of SARS-CoV-2 genetically fused to oligoDOM, a self-assembling domain which improves antigen immunogenicity. OVX033 including N as an antigenic target is proposed as new vaccine candidate providing broad-spectrum protection against sarbecoviruses.
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- * Genetic analysis showed multiple lineages of the virus co-circulating in the infected farm, linking it to human cases from the same period.
- * Other farms had lower infection rates, but one contained a mink coronavirus similar to earlier strains found in Danish farms, raising concerns about potential viral recombination and varied clinical impacts among infected farms.
Objective: There is extensive evidence that SARS-CoV-2 replicates in the gastrointestinal tract. However, the infectivity of virions in feces is poorly documented. Although the primary mode of transmission is airborne, the risk of transmission from contaminated feces remains to be assessed.
View Article and Find Full Text PDFGiven the difficulty of measuring pathogen transmission in wildlife, epidemiological studies frequently rely on cross-sectional seroprevalence. However, seropositivity indicates only exposure to a pathogen at an unknown time. By allowing to obtain repeated test results from individuals sampled multiple times over an extended period, longitudinal data help reduce this uncertainty.
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