Publications by authors named "E Miyagi"
Traditional mouse models for deep vein thrombosis (DVT), frequently utilized in research focused on cancer-associated thrombosis (CAT), reliably induce thrombus formation by obstructing blood flow (BF) in the inferior vena cava (IVC), which does not occur in humans. Therefore, to develop a new DVT model for CAT studies, we implanted an ameroid constrictor (AC), a hygroscopic casein C-shape device, around the IVC and aorta of immunocompromised mice. We evaluated the thrombus 3 and 8 days post-AC implantation and compared it with the traditional model 2 days post-vena cava ligation.
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- Turner syndrome is a genetic disorder caused by the deletion of one X chromosome, leading to diverse karyotypes and phenotypes, but predicting phenotypes remains challenging due to mosaicism.
- A study included 487 Turner women with non-mosaic X chromosome structural rearrangements and found prevalence rates of short stature (72.4%) and ovarian dysfunction (78.8%) linked to specific deletion groups.
- Understanding the specific X chromosome breakpoints is crucial for managing Turner syndrome, particularly for predicting and addressing ovarian dysfunction and future fertility issues.
Maternal and neonatal outcomes of occiput posterior vaginal delivery.
J Obstet Gynaecol Res
January 2025
Article Synopsis
- The study investigates the maternal and neonatal outcomes of fetal occiput posterior (OP) deliveries in Japan, as OP positions are often linked to worse maternal outcomes compared to occiput anterior (OA) positions.
- Conducted at a tertiary hospital, the study analyzed data from 13,852 singleton, vaginal deliveries after 37 weeks from January 2000 to May 2023, finding a significantly higher incidence of complications like assisted deliveries and perineal lacerations in the OP group compared to the OA group.
- Although OP deliveries led to more maternal complications, such as increased labor time and risks of lacerations and hemorrhage, neonatal outcomes remained similar between the two groups.
Article Synopsis
- The study aimed to assess the effectiveness and safety of robot-assisted radical hysterectomy (RARH) in treating cervical cancer, comparing it to traditional surgical methods.
- A total of 100 patients underwent RARH, achieving a high success rate with minimal blood loss and low recurrence rates after 2 years.
- Results showed strong oncological outcomes, with RARH yielding excellent recurrence-free survival (RFS) and overall survival (OS) rates, suggesting its viability as a surgical option for cervical cancer.
Article Synopsis
- Cervical cancer screening rates in Japan are low, making prenatal visits an important opportunity for women to undergo cervical cytology tests during pregnancy, according to this study.
- The study analyzed data from 2,725 participants, revealing that certain factors such as smoking, younger age, lower education levels, and specific sampling methods were linked to higher rates of abnormal cervical results (ASC-US).
- Results showed that nearly 40% of participants with abnormal results thought they had “no abnormalities,” highlighting the need for better patient education and follow-up for those with detected issues.