Novel Treatment of 3D-Printed Short-Carbon-Fiber-Reinforced Polyamide (3D-SCFRPA66) Using Homogeneous Low-Potential Electron Beam Irradiation (HLEBI) and Ductility Enhancement.

In short-carbon-fiber-reinforced polyamide 66 articles shaped by 3D printing (3D-SCFRPA66), the interfaces between printed layers are often susceptible to damage, and the composite is excessively brittle. Therefore, a novel treatment for 3D-printed short-carbon-fiber-reinforced polyamide (3D-SCFRPA66) using homogeneous low-potential electron beam irradiation (HLEBI) to enhance tensile properties was investigated. In 3D-SCFRPA66 samples, ductility was measured based on the following parameters: strain at tensile strength (corresponding to homogeneous deformation) () and resistance energy to homogeneous deformation, a measure of toughness (), which were both substantially increased.

[A case of Parkinson's disease with marked head drop after administration of donepezil hydrochloride].

A 76-year-old woman with a 2-year history of Parkinson's disease presented with dropped head, which had developed rapidly after she had been prescribed donepezil hydrochloride (DNP) at 3 ‍mg/day. After one month of medication, the extent of the head drop reached 90°. Examination revealed hypertrophy of the left sternocleidomastoid muscle, but no weakness of the extensor muscles in the cervical region.

Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum.

Kainate (KA)-type glutamate receptors (KARs) are implicated in various neuropsychiatric and neurological disorders through their ionotropic and metabotropic actions. However, compared to AMPA- and NMDA-type receptor functions, many aspects of KAR biology remain incompletely understood. Our study demonstrates an important role of KARs in organizing climbing fiber (CF)-Purkinje cell (PC) synapses and synaptic plasticity in the cerebellum, independently of their ion channel or metabotropic functions.

[Juvenile-onset anti-nuclear matrix protein 2 (NXP-2) antibody-positive dermatomyositis with joint contractures before manifestation of myositis: a case report].

A 23-year-old man was admitted to our hospital with a one-year history of muscle weakness and atrophy. He had noticed contractures of the fingers of both hands from the age of 18. Examination revealed a skin rash including heliotrope rash and Gottron's sign, joint contractures in the extremities, dysphagia, extensive muscle weakness and marked muscle atrophy.

Establishment of artificial intelligence model for precise histological subtyping of lung adenocarcinoma and its application to quantitative and spatial analysis.

Background: The histological subtype of lung adenocarcinoma is a major prognostic factor. We developed a new artificial intelligence model to classify lung adenocarcinoma images into seven histological subtypes and adopted the model for whole-slide images to investigate the relationship between the distribution of histological subtypes and clinicopathological factors.

Methods: Using histological subtype images, which are typical for pathologists, we trained and validated an artificial intelligence model.