Publications by authors named "E Misas"
Background: Reports of fluconazole-resistant bloodstream infections are increasing. We describe a cluster of fluconazole-resistant bloodstream infections identified in 2021 on routine surveillance by the Georgia Emerging Infections Program in conjunction with the Centers for Disease Control and Prevention.
Methods: Whole-genome sequencing was used to analyze bloodstream infections isolates.
Article Synopsis
- Zoonotic sporotrichosis is a neglected fungal disease mainly caused by Sporothrix brasiliensis, transmitted from cats to humans, with a significant outbreak currently occurring in Brazil.
- The study involved whole-genome sequencing of Sporothrix isolates collected from sporotrichosis cases in Brazil, Colombia, and the USA between 2013 and 2022, aiming to explore the genomic epidemiology of the disease.
- Out of 72 isolates studied, 93% were from Brazil, with the majority being S. brasiliensis; comprehensive phylogenetic analyses revealed distinct genetic clades correlating with geographical origins and diverse transmission pathways.
Bimodal distribution of azole susceptibility in isolates in Brazil.
Antimicrob Agents Chemother
April 2024
Article Synopsis
- An emerging fungal pathogen called Sporothrix spp. poses treatment challenges, especially in human and cat sporotrichosis cases.
- Antifungal testing on 61 isolates from Brazil revealed that about 50% exhibited high resistance to itraconazole.
- Phylogenetic analysis showed that resistant isolates come from diverse clades, and SNP analysis identified a specific gene mutation linked to azole resistance in two isolates, but no other resistance mechanisms were found in the others.
Unlabelled: Since 2016, in Colombia, ongoing transmission of has been reported in multiple cities. Here, we provide an updated description of genomic epidemiology and the dynamics of antifungal resistance in Colombia. We sequenced 99 isolates from cases with collection dates ranging from June 2016 to January 2021; the resulting sequences coupled with 103 previously generated sequences from cases were described in a phylogenetic analysis.
View Article and Find Full Text PDF