Publications by authors named "E Migneco"

Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts.

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Article Synopsis
  • Canine transmissible venereal tumor (CTVT) is a unique cancer that has survived for thousands of years by spreading through cell transfer from one dog to another.
  • Researchers analyzed 546 CTVT exomes to create a timeline and track its global spread, discovering a specific mutational process that occurred early in its evolution but later disappeared.
  • The study found that while CTVT shows minimal ongoing positive selection and some negative selection in key genes, random genetic drift plays a major role in the long-term evolution of this cancer.
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The use of existing detecting systems developed for nuclear physics studies allows collecting data on particle and ion production cross-sections in reactions induced by Oxygen and Carbon beams, of interest for hadrontherapy and heavy-ion risk assessment. The MULTICS and GARFIELD apparatus, together with the foreseen experiments, are reviewed.

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The energetic proton emission has been investigated as a function of the reaction centrality for the system (58)Ni + (58)Ni at 30A MeV. Extremely energetic protons (E(NN)(p) > or = 130 MeV) were measured and their multiplicity is found to increase almost quadratically with the number of participant nucleons, thus indicating the onset of a mechanism beyond one- and two-body dynamics.

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