The physical and chemical stability of cisplatin (Teva) in concentrate and diluted in sodium chloride 0.9%.

Aim Of The Study: The subject of study was the stability of cisplatin in concentrate in glass vials and diluted in polyethylene (PE) bags stored at 15-25°C for up to 30 days.

Material And Methods: Original vials of cisplatin injection (1 mg/ml, Teva) were stored at room temperature and subjected to re-piercing after 1, 2, 3, 7, 14, 21, 28 and 30 days following the initial piercing. Cisplatin infusions at nominal concentrations of 0.

[Biochemical and electrophysiological studies in subjects with occupational exposure to lead poisoning].

In 36 men working in occupations with lead exposure the conduction velocity was measured in the motor fibres of the median, ulnar and peroneal nerves, and determinations were carried out of blood lead level, 24-hour urinary excretion of lead and delta-aminolaevulinic acid, and activity of delta-aminolaevulinic acid dehydratase in the erythrocytes. The comparison of the results of electrophysiological and biochemical investigations shows that lesions of the peripheral nervous system are not always correlated with the biochemical indices of lead poisoning and that peripheral nervous system damage, mainly subclinical, may develop in early period of exposure.

[Fertility in the population of women with epilepsy].

Retrospective inquiry investigations of 263 women with epilepsy at the age above 15 years demonstrated that the reproductive functions in these women were twice lower than in the general population of this region. The number of unmarried was 7% above that in the population, 25% of married epileptic women had no children, and most married women controlled the birth rate resorting frequently to artificial abortions. The index of perinatal mortality of the newborns, dead fetuses and early deaths) was over three times higher than in the population: 88.