Publications by authors named "E Mery"
Background: Mesothelioma is a rare and aggressive malignant neoplasm arising from mesothelial cells, which occasionally manifests recurrent fusions. EWSR1/FUS-CREB, YY1, MAP3K8, NR4A3, and ALK-rearranged proliferations have been reported in limited series with no clear histological or clinical correlations, limiting clinicians' ability to assess prognosis and integrate these new entities into therapeutic decisions. The aim of this study was to better characterize these rearranged proliferations histologically, molecularly, and clinically.
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- A study was conducted on the genomic profiles of uterine smooth muscle tumors, focusing on two types: fumarate hydratase deficient leiomyomas and leiomyomas with bizarre nuclei, to understand their relationship with clinical outcomes.
- All patients in the study were alive without disease after an average follow-up of 87.3 months, leading to the conclusion that certain genomic indices (GI) were not reliable indicators of malignancy in these tumor types.
- The research identified three groups of tumors based on genomic alterations and their associated GIs, suggesting that a GI less than 10 indicates benignity, while a GI greater than 10 does not necessarily indicate malignancy, offering a new diagnostic approach for these tumors
Introduction: Villitis of unknown etiology (VUE) is a histopathological lesion associated with adverse neonatal outcomes. We seek to define the obscure relationship between the severity and distribution of VUE and adverse neonatal outcomes.
Methods: A retrospective chart review was conducted of pathologic findings from singleton placentas diagnosed with VUE between 2013 and 2019.
[Diagnosis of uterine sarcomas and rare uterine mesenchymal tumours with malignant potential. Guidelines of the French Sarcoma Group and Rare Gynaecological Tumours].
Bull Cancer
January 2024
Article Synopsis
- The classification of uterine sarcomas is evolving with the discovery of new types linked to specific genetic changes, categorizing them into complex genomic and simple genomic sarcomas.
- The most common types include leiomyosarcomas and endometrial stromal sarcomas, with various histological subtypes that have differing degrees of aggression.
- Recent advances in molecular diagnostics and targeted therapies are enhancing the identification and treatment strategies for these tumors.
Background: Embryonal rhabdomyosarcomas (ERMS) of the uterine cervix and corpus are rare pediatric tumors usually associated with a late age of onset and frequent somatic DICER1 mutation. It may also develop in the context of a familial predisposition such as DICER1 syndrome requiring specific medical care for children and young adults at risk for a broad range of tumors.
Case Presentation: This is a case of a prepubescent 9-year-old girl who was presented to our department for metrorrhagias due to a vaginal cervical mass, initially classified as a müllerian endocervical polyp on negative myogenin immunostaining.