Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping.

Hospitalized COVID-19 patients exhibit diverse immune responses during acute infection, which are associated with a wide range of clinical outcomes. However, understanding these immune heterogeneities and their links to various clinical complications, especially long COVID, remains a challenge. In this study, we performed unsupervised subtyping of longitudinal multi-omics immunophenotyping in over 1,000 hospitalized patients, identifying two critical subtypes linked to mortality or mechanical ventilation with prolonged hospital stay and three severe subtypes associated with timely acute recovery.

Safety of dorsal screw penetration at the proximal holes of volar locking plates.

Tendon-related complications comprise a significant portion of overall complications following volar locked plating of distal radius fractures. While much is known about the effect of prominent hardware in the volar and dorsal metaepiphyseal region of the distal radius, less is known about the effect of hardware prominence in the dorsal meta-diaphyseal region. The purpose of this anatomic study was to evaluate the safety of dorsal screw penetration at the proximal holes of volar locking plates.

Molecular mimicry as a mechanism of viral immune evasion and autoimmunity.

Mimicry of host protein structures, or 'molecular mimicry', is a common mechanism employed by viruses to evade the host's immune system. Short linear amino acid (AA) molecular mimics can elicit cross-reactive antibodies and T cells from the host, but the prevalence of such mimics throughout the human virome has not been fully explored. Here we evaluate 134 human-infecting viruses and find significant usage of linear mimicry across the virome, particularly those in the Herpesviridae and Poxviridae families.