Antimycobacterial effect of extract and its components from Rheum rhaponticum.

The global threat of tuberculosis demands the search for alternative antimycobacterial drugs. The present study examined roots and petioles from Rheum rhaponticum for antimycobacterial activity. Crude methanol extracts and eight phenolic compounds isolated by preparative column chromatography were tested against Mycobacterium tuberculosis H37Ra and M.

Development of vessels in the foetal cortical transplant depending on the place of grafting in the rat brain.

Formation of new blood vessels within the graft is crucial for the survival of brain grafts. Moreover, it must occur rapidly to prevent ischaemic changes in the grafted neurons. A study was made of the development of the vascular system in the foetal cortical grafts depending on the place of grafting in the rat brain.

[Effect of histological technics on the volume and weight of various brain structures of rats at the early stages of life].

The aim of the studies was to elaborate technical procedure of material preparation for quantitative studies and determination of correction coefficients of morphometric parameters in dependence on histological procedures. Moreover, volume changes of the rat substantia nigra and striatum (structures degenerating in Parkinson's disease) during the first half year of life were estimated. As fixatives 4 and 8% formaldehyde in 4 and 20 degrees C were used.

[Morphological evaluation of tissue and cellular components of the corpus striatum, globus pallidus and substantia nigra in 7-day-old rats].

The aim of the study was the morphometric evaluation of tissue and cell composition of brain structures which are involved into transplantation in experimental model of parkinsonism in the rat-substantia nigra as the implanted structure and caudate-putamen as the host structure into which the graft is placed. Three parts of caudate-putamen (anterior, medial and posterior), three parts of substantia nigra (compact, reticular and lateral) as well as pallidum were investigated in 7-day-old rat. It was found that the density of nerve cells is highest in medial part (2236/l mm2), lower in anterior part (2129/1 mm2) and the lowest in posterior one (1842/1 mm2).