Publications by authors named "E Mcgrath"
Background: Interstitial lung diseases (ILD) are poorly understood disorders characterised by diffuse damage to the lung parenchyma, with inflammation and fibrosis. Some manifest a progressive fibrotic phenotype with high fatality and limited treatment options, such as idiopathic pulmonary fibrosis (IPF).
Summary: The degree to which inflammation plays a role in fibrosis progression is unknown.
Background: With greater availability of participant data and biobank repositories following clinical trial completion, adequately describing future data and biological sample reuse plans to trial participants is increasingly important. We evaluated how trial teams currently describe current and future use of participant data and biological samples in participant information leaflets (PILs).
Methods: Retrospective qualitative analysis of 240 PILs (182 clinical trials) in Ireland and the UK.
A WHO remit to improve global standards for medical products of human origin.
Bull World Health Organ
October 2024
In recent decades, considerable advances have been made in assuring the safety of blood transfusion and organ transplantation. However, with the increasing movement of medical products of human origin across international boundaries, there is a need to enhance global norms and governance. These products, which include blood, organs, tissues, cells, human milk and faecal microbiota, are today crucial for health care but they also pose unique risks due to their human origin, such as disease transmission and graft failure.
View Article and Find Full Text PDFCelebrating the registration of 9.000 patients treated with CAR T cells in the EBMT registry: Collection of real-world data in the context of hematopoietic cellular therapies.
Best Pract Res Clin Haematol
June 2024
Article Synopsis
- The European Society for Blood and Marrow Transplantation (EBMT) has established a continental registry over 30 years, currently housing data on over 700,000 patients and 800,000 transplants, which supports various research and benchmarking efforts in hematopoietic cell transplantation.
- The introduction of CAR-T cell therapies, which could significantly impact blood and marrow transplantation practices, prompted EBMT to create a Cellular Therapy Form that registers CAR-T cell treated patients and collects detailed outcome data.
- The EBMT Registry received approval from the European Medicines Agency in 2019 and now holds information on more than 9,000 patients treated with CAR-T cells, facilitating analyses and evaluations of these therapies' medical value within different contexts
Background: Many youth saw a rise in body mass index and obesity during the COVID-19 pandemic associated with virtual schooling and a lack of physical exercise options due to lockdown orders. However, the impact of the worldwide COVID-19 pandemic on body mass index in HIV-infected youth on anti-viral therapy has not been studied.
Objective: This study examined COVID-19's impact on body mass index in 157 behaviorally acquired and 39 perinatally acquired youth living with HIV.