Publications by authors named "E McPherson"
Article Synopsis
- The study investigates chronic periprosthetic joint infection (PJI) after joint replacements, focusing on how a special irrigant can disrupt the biofilm covering the implant and enhance microbial detection.
- Researchers compared two methods (culture and Next Generation Sequencing) to identify microbes in samples from 38 Total Knee Arthroplasty patients before and after irrigation with the Bactisure Lavage.
- Results showed a decrease in detectable organisms with culture techniques post-lavage, while NGS identified many more microbes (177 vs. 126) afterward, including 135 organisms not detected before, indicating a hidden diversity of microbes in the biofilm.
Background: With advancements in perioperative care, joint replacement (JR) surgery is undergoing a transition from opacified in-patient institutions to nimble out-patient Ambulatory Surgical Centers (ASC). The goal of JR in ASC setting is safe patient discharge with subsequent rehabilitation without readmission. Multi-modal preoperative rehabilitation (MMPR) is a novel field of perioperative care, encompassing comprehensive parameters to ensure smooth transition from fitness for surgery to JR in outpatient setting.
View Article and Find Full Text PDFPatellar failure in total knee arthroplasty is a major source of complications postoperatively. Previous patellar failure reports commonly cited dissociations of modular and metal-backed patellar implants. However, mechanical breakage of monoblock all-polyethylene patellar implants is very rare.
View Article and Find Full Text PDFArticle Synopsis
- This study investigated TRL1068, a monoclonal antibody designed to tackle chronic periprosthetic joint infections (PJI) caused by biofilms, in 15 patients.
- TRL1068 was given as a single pre-surgical infusion in three different doses, in addition to targeted antibiotics, and showed a favorable safety profile with no adverse events linked to the treatment.
- Results indicated a significant reduction in implant bacteria in 3 out of 11 patients receiving TRL1068, with no relapses of infection by day 169, suggesting it could be a promising option for PJI treatment.
Background: Infection rates in revision total hip arthroplasty are lower when antibiotic loaded cemented stems are utilized. Inspired by this technique, a point-of-care coating of antibiotic-loaded calcium sulfate (CaSO) was applied to cementless revision stems in aseptic revision and 2nd stage reimplantation total hip arthroplasty.
Methods: One hundred eleven consecutive femoral stems were coated.