Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates.

To evaluate pharmacokinetic parameters and ocular hypotensive effects of cromakalim prodrug 1 (CKLP1) in normotensive large animal models. Optimal CKLP1 concentration was determined by dose response and utilized in short- (5-8 days) and long-term (60 days) evaluation in hound dogs ( = 5) and African Green Monkeys ( = 5). Blood pressure was recorded 3-5 times per week with a tail cuff.

A medical nutrition therapy primer for childhood asthma: current and emerging perspectives.

Asthma is the most common chronic disease in children. Prevalence has increased in the past 2 decades and has reached a plateau of approximately 9% of children in the United States, affecting about 6.7 million children.

Nutritional management of children who have food allergies and eosinophilic esophagitis.

Over the past decade, eosinophilic esophagitis has become increasingly prevalent in the United States. One of the effective treatment approaches is dietary management, which aims to eliminate exposure to food allergens. Approaches to dietary management include the use of elemental diets, elimination diets, and tailored elimination diets, each of which poses potential nutrition risks.

Biotin uptake by human colonic epithelial NCM460 cells: a carrier-mediated process shared with pantothenic acid.

Previous studies showed that the normal microflora of the large intestine synthesizes biotin and that the colon is capable of absorbing intraluminally introduced free biotin. Nothing, however, is known about the mechanism of biotin absorption in the large intestine and its regulation. To address these issues, we used the human-derived, nontransformed colonic epithelial cell line NCM460.