Publications by authors named "E McCance"

The purpose of this report is to present the outcomes of Descemet's stripping endothelial keratoplasty (DSEK), followed by deep anterior lamellar keratoplasty (DALK), as an alternative to penetrating keratoplasty (PKP) for different indications. Patients in this retrospective case series underwent manual DSEK, followed by manual DALK, for tectonic and/or visual reasons. It includes three cases that underwent DSEK followed by DALK as an alternative to PKP for the following conditions: failed PKP and stromal scarring, aphakic bullous keratopathy and herpetic stromal scarring, and herpetic corneal perforation.

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Purpose: To report the front corneal versus central and paracentral corneal changes after Bowman layer transplantation for keratoconus in a tertiary hospital in the United Kingdom.

Methods: Five eyes of 5 patients receiving Bowman layer transplant for advanced keratoconus in Royal Gwent Hospital (Newport, United Kingdom) were included. Preoperative and postoperative visual acuity; Kmax; Kmean, and corneal cylinder in the front cornea, 4.

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Article Synopsis
  • Ocular trauma can lead to severe vision impairment, particularly through conditions like commotio retinae and traumatic optic neuropathy (TON), which affect photoreceptors and retinal ganglion cells (RGC).
  • In a rat model of blunt ocular trauma, researchers investigated the role of caspase-2 in causing RGC and photoreceptor death, utilizing techniques like Western blotting and electroretinography (ERG) to assess cell survival and retinal function.
  • The study found that caspase-2 is involved in RGC death after injury, suggesting that targeting caspase-2 with RNA interference (siCASP2) may offer a potential treatment strategy for preventing RGC degeneration, though it does not protect
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Oxygen is an important drug frequently used in the management of acutely unwell hospital patients. However, oxygen overuse can have fatal side effects particularly for those patients at risk of iatrogenic hypercapnia. British Thoracic Society Guidelines state that oxygen must be prescribed for all patients, with target saturations stipulated on the prescription for patient safety.

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