Publications by authors named "E Mattingly"
Magnetic Particle Imaging (MPI) was introduced in 2005 as a promising, tracer-based medical imaging modality with the potential for high sensitivity and spatial resolution. Since then, numerous preclinical devices have been built but only a few human-scale devices, none of which targeted functional neuroimaging. In this work, we probe the challenges of scaling the technology to meet the needs of human functional neuroimaging with sufficient sensitivity for detecting the hemodynamic changes following brain activation with a spatio-temporal resolution comparable to current functional Magnetic Resonance Imaging (fMRI) approaches.
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- Magnetic fields that switch at high frequencies (kHz) can cause peripheral nerve stimulation (PNS) in the body, and this has primarily been studied below 10 kHz.
- Previous studies above ~25 kHz showed inconsistent results with high variability, but new research involving 8 volunteers measured PNS at frequencies from 200 Hz to 88.1 kHz.
- Results indicated that instead of continuously decreasing, the PNS thresholds hit a minimum around 25 kHz and then increased by 39% from that point to 88.1 kHz, highlighting the need for more research on the biological mechanisms behind magnetostimulation at these higher frequencies.
Magnetic nanoparticles (MNPs) are used extensively across numerous disciples, with applications including Magnetic Particle Imaging (MPI), targeted hyperthermia, deep brain stimulation, immunoassays, and thermometry. The assessment of MNPs, especially those being designed for MPI, is performed with magnetic particle spectrometers, relaxometers, loop tracers, or similar devices. Despite the many applications and the need for particle assessment, there are few consolidated resources for designing or building such a MNP assessment system.
View Article and Find Full Text PDFNon-invasive functional brain imaging modalities are limited in number, each with its own complex trade-offs between sensitivity, spatial and temporal resolution, and the directness with which the measured signals reflect neuronal activation. Magnetic particle imaging (MPI) directly maps the cerebral blood volume (CBV), and its high sensitivity derives from the nonlinear magnetization of the superparamagnetic iron oxide nanoparticle (SPION) tracer confined to the blood pool. Our work evaluates functional MPI (fMPI) as a new hemodynamic functional imaging modality by mapping the CBV response in a rodent model where CBV is modulated by hypercapnic breathing manipulation.
View Article and Find Full Text PDFBackground: Cognitive-communication impairments following acquired brain injury (ABI) can have devastating effects on a person's ability to participate in community, social, vocational, and academic preinjury roles and responsibilities. Guidelines for evidence-based practices are needed to assist speech-language pathologists (SLPs) and other rehabilitation specialists in the delivery of cognitive rehabilitation for the adult population.
Purpose: The American Speech-Language-Hearing Association, in conjunction with a multidisciplinary panel of subject matter experts, developed this guideline to identify best practice recommendations for the delivery of cognitive rehabilitation to adults with cognitive dysfunction associated with ABI.