Exploring histological remission in pediatric patients with celiac disease.

In response to the article presented by Laura Rodríguez-Martínez et al., which discusses mucosal healing rates in celiac disease and the risk factors for persistent damage despite a gluten-free diet in adults, we present a review of biopsies from pediatric patients with celiac disease performed at our center between 2001 and 2020. Notably, there is a higher rate of mucosal healing compared to adults (83%), and factors such as age at diagnosis, histological involvement, and anti-tissue transglutaminase antibody levels at diagnosis do not appear to be significant risk factors, unlike in adults.

Faecal lipid profile as a new marker of fat maldigestion, malabsorption and microbiota.

Background: Fat malabsorption in children with cystic fibrosis (CF) leads to poor nutritional status and altered colonic microbiota. This study aimed at establishing the faecal lipid profile in children with CF, and exploring associations between the faecal lipidome and microbiota.

Methods: Cross-sectional observational study with children with CF and an age-matched control group.

Long-term evaluation of faecal calprotectin levels in a European cohort of children with cystic fibrosis.

Objective: Intestinal inflammation with contradictory data on faecal calprotectin (fCP) levels is documented in patients with cystic fibrosis (CF). The aim of this study was to longitudinally evaluate fCP in a cohort of children with CF and their relationship with clinical variables.

Design: Prospective observational study to assess evolution of fCP levels, primary aimed at improving fat absorption.

Effect of beta-glucan supplementation on cystic fibrosis colonic microbiota: an in vitro study.

Background: Children with cystic fibrosis (CF) present with gut dysbiosis, and current evidence impedes robust recommendations on the use of prebiotics. This study aimed at establishing the prebiotic potential of a commercial beta-glucan on the in vitro colonic microbiota of a child with CF compared to a healthy counterpart (H).

Methods: A dynamic simulator of colonic fermentation (twin-SHIME® model) was set up including the simulation of the proximal (PC) and distal colon (DC) of the CF and the H subjects by colonizing the bioreactors with faecal microbiota.

Study of the immune response in celiac patients with selective IgA deficiency who start a gluten-free diet.

Studies are scarce regarding IgG anti-tissue transglutaminase 2 (tTG) normalization in selective IgA deficient (SIgAD) celiac disease (CD) patients after beginning a gluten free diet (GFD). The aim of this study is to analyse the decreasing dynamics of IgG anti-tTG in patients diagnosed with CD who start a GFD. To achieve this objective, IgG and IgA anti-tTG levels at diagnosis and during follow-up in 11 SIgAD CD patients and in 20 IgA competent CD patients were retrospectively evaluated.