The Pathogenetic Role of RANK/RANKL/OPG Signaling in Osteoarthritis and Related Targeted Therapies.

Osteoarthritis (OA) is the most common degenerative joint disease and affects millions of people worldwide, particularly the elderly population. The pathophysiology of OA is complex and involves multiple factors. Several studies have emphasized the crucial role of inflammation in this process.

Do social capital and the quality of institutions affect waste recycling?

In a social capital framework, the quality of institutions and generalised social trust enhance attitudes towards disposal practices that are less environmentally invasive for the. This study aims to improve our empirical knowledge of this relationship through panel data models to show that waste recycling is affected by social capital and government effectiveness. The study uses Italian annual provincial data (NUTS-3 level) for 2004-2016 period to show that social capital and the quality of institutions are extremely important in determining waste recycling behavior.

Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy.

Absence epilepsy is frequently associated with cognitive dysfunction, although the underlying mechanisms are not well understood. Here we report that some forms of hippocampal synaptic plasticity are abnormal in symptomatic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Metabotropic Glu 1/5 receptor-mediated long term depression (LTD) at Schaffer collateral CA1 synapses is significantly reduced in symptomatic, 5-6 months old WAG/Rij rats compared to age-matched non epileptic control rats.

The perception of air pollution and noise in urban environments: A subjective indicator across European countries.

Although urbanization has been a fundamental feature of economic development, increasingly important concerns about environmental quality have led to a wide-ranging debate about the concept of urban sustainability. In this paper, we examine how living in urban areas affects people's perceptions of two specific aspects of environmental quality, namely, air pollution and noise. Specifically, for every country, we develop an indicator that is based on these perceptions.