Publications by authors named "E Martinsen"
Advances in RNA therapeutics for modulation of 'undruggable' targets.
Prog Mol Biol Transl Sci
March 2024
Over the past decades, drug discovery utilizing small pharmacological compounds, fragment-based therapeutics, and antibody therapy have significantly advanced treatment options for many human diseases. However, a major bottleneck has been that>70% of human proteins/genomic regions are 'undruggable' by the above-mentioned approaches. Many of these proteins constitute essential drug targets against complex multifactorial diseases like cancer, immunological disorders, and neurological diseases.
View Article and Find Full Text PDFObjective: To investigate changes in FPs' self-reported clinical practices after participation in a comprehensive 1-year cognitive behavioural therapy (CBT) training course.
Design: Cross-sectional study.
Setting: Norway.
Introduction: Negative affect and anxiety frequently precede the onset of drug use in those with substance use disorder (SUD). Low self-esteem may increase the risk of relapse. We examined the short-term effects of exercise on affect, anxiety, and self-esteem in inpatients with poly-SUD.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the differences in pulmonary fungal and bacterial microbiota between sarcoidosis patients and healthy controls, finding notable variations.
- Significant findings include that Aspergillus was predominant in the samples from sarcoidosis patients, while bacterial diversity was lower compared to controls.
- Additionally, lower levels of antimicrobial peptides (AMPs) were observed in sarcoidosis patients, suggesting a potential link between the microbiota and the immune system in this condition.