Postsynaptic antagonism by 4-aminopyridine of ketamine effect in frog (Hyla crepitans) neuromuscular junctions.

The action of ketamine (50 microM) and 4-aminopyridine (4-AP) (50 microM) on the frog (Hyla crepitans) neuromuscular junction using standard intracellular recording techniques was investigated. In our experiments the amplitude of evoked end plate potential was decreased by ketamine and increased by 4-AP, which is similar to the effects reported by other investigators. However, novel effects of the drugs on postsynaptic acetylcholine receptors were detected when miniature end plate potential (MEPP) amplitude and time-course were analyzed.

Comparison of midazolam (Ro 21-3981) and diazepam as complement of ketamine-air anesthesia in children.

A single-blind, randomized, prospective, comparative clinical trial was performed in 90 (30 X 3) pediatric patients, comparing a new water-soluble benzodiazepine, midazolam (Ro 21-3931) and ketamine-air (8 mg . kg-1) by intramuscular or intravenous routes at equipotent dose (0.2 mg .