Publications by authors named "E Margo Molhoek"
E. coli-Shigella species are a cryptic group of bacteria in which the Shigella species are distributed within the phylogenetic tree of E. coli.
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- NETs (neutrophil extracellular traps) are an essential part of the innate immune system that help combat infections.
- The study explored how the peptide LL-37 affects the formation of NETs by disrupting the nuclear membrane in neutrophils, showing that LL-37 enhances NET formation when combined with other stimuli like PMA or Staphylococcus aureus.
- Key findings included the observation that the ability of LL-37 to induce NETs is linked to its hydrophobic properties and that it actively moves toward the nucleus to assist in membrane disruption.
Neutrophil extracellular traps (NETs) have been described as a fundamental innate immune defence mechanism. They consist of a nuclear DNA backbone associated with different antimicrobial peptides (AMPs) which are able to engulf and kill pathogens. The AMP LL-37, a member of the cathelicidin family, is highly present in NETs.
View Article and Find Full Text PDFBecause hyponatraemia can be caused by many disorders, the diagnostic approach to hyponatraemia can be challenging for physicians. Causes of hyponatraemia can be classified according to a combination of laboratory parameters (e.g.
View Article and Find Full Text PDFThe broad-spectrum defense system based on host defense peptides (HDPs) is evolutionary very old and many invertebrates rely on this system for protection from bacterial infections. However, in vertebrates the system remained important in spite of the superposition of a very sophisticated adaptive immune system. The cathelicidins comprise a major group of HDPs in mammals.
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