Pan-PPAR agonist lanifibranor improves insulin resistance and hepatic steatosis in patients with T2D and MASLD.

Background & Aims: Lanifibranor is a pan-PPAR agonist that improves glucose/lipid metabolism and reverses steatohepatitis and fibrosis in adults with MASH. We tested its effect on insulin resistance at the level of different target tissues in relationship to change in intrahepatic triglyceride (IHTG) content.

Methods: This phase 2, single center, study randomized (1:1) 38 patients with T2D and MASLD to receive lanifibranor 800 mg or placebo for 24 weeks.

Diffusion and thermodynamic properties of lithium polysulfides in different solvents: a molecular dynamics approach.

Li-S batteries are promising alternatives due to their proven increased gravimetric capacity compared to Li-ion batteries. However, their development is hindered by many technical issues, one of the most challenging being the dissolution and shuttle of polysulfide species, which causes irreversible loss of cathode material leading to rapid capacity fading. Among the possible strategies to mitigate this effect, the choice of suitable solvents is easy to implement and has large room for improvement.

Anode-free post-Li metal batteries.

Anode-free metal batteries (AFMBs) are a new architecture of battery technology that relies solely on current collectors (CCs) at the anode side, eliminating the need for traditional metal anodes. This approach can pave the way for higher energy densities, lower manufacturing costs, and lower environmental footprints associated with metal batteries. This comprehensive review provides an in-depth exploration of AFMB technology, extending its scope beyond lithium and into a broader range of metals (sodium Na, potassium K, magnesium Mg, zinc Zn and aluminum Al).

Feammox bacterial biofilm formation in HFMB.

Nitrogen pollution has been increasing with the development of industrialization. Consequently, the excessive deposition of reactive nitrogen in the environment has generated the loss of biodiversity and eutrophication of different ecosystems. In 2005, a Feammox process was discovered that anaerobically metabolizes ammonium.

Coupling of the Feammox - Anammox pathways by using a sequential discontinuous bioreactor.

Treating nitrogenous compounds in wastewater is a contemporary challenge, prompting novel approaches for ammonium (NH) conversion to molecular nitrogen (N). This study explores the classic anaerobic ammonium oxidation process (Anammox) coupled to the iron-dependent anaerobic ammonium oxidation process (Feammox) in a sequential discontinuous bioreactor (SBR) for NH removal. Feammox and Anammox cultures were individually enriched and combined, optimizing the coupling, and identifying key variables influencing the enrichment process.