Aminoguanidine-based bioactive proligand as AIEE probe for anticancer and anticovid studies.

The emission features of a novel bioactive compound, 1,3-bis(2-hydroxy-3,5-diiodophenyl-methylideneamino)guanidine is found impressive with aggregation induced emission enhancement. The nitrogen and iodine rich multidentate proligand was characterized physicochemically. SCXRD and Hirshfeld surface investigation have revealed the presence of significant triangular iodine bonding apart from hydrogen bonding, weak C-H⋯π and π⋯π intermolecular interactions.

Copper perchlorate catalyzed oxidative cyclisation of a novel bishydrazone ligand, formation of an unusual copper complex and in vitro biological implications.

A novel hexadentate bishydrazone ligand, 1,10-bis(di(2-pyridyl)ketone) adipic acid dihydrazone (HL) is synthesized and characterized. With copper perchlorate as a catalytic oxidant, the ligand undergoes oxidative cyclisation and resulted in the formation of an unusual copper complex [Cu(L)Cl]ClO (1), where L is 3-(2-pyridyl)triazolo[1,5-a]-pyridine. The Cu(II) complex was characterized physicochemically, while the molecular structure was confirmed by single crystal X- ray diffraction.

A comparison of changes in venous lactate and haematocrit during fluid resuscitation of dengue haemorrhagic fever.

Background: Judicious fluid resuscitation and stringent monitoring of clinical parameters improve the outcome of dengue haemorrhagic fever (DHF). The usefulness of serum lactate to monitor adequate fluid therapy has not been adequately explored.

Methods: An observational study was conducted in Sri Lanka, recruiting 162 DHF patients within 12 h of diagnosis of the critical phase.

A novel manganese(II) bisthiocarbohydrazone complex: Crystal structures, Hirshfeld surface analysis, DFT and molecular docking study with SARS-CoV-2.

A novel Mn(II) complex [Mn(HL)Cl]•HO () of a ditopic ligand 1,5-bis(2-benzoylpyridine) thiocarbohydrazone (HL) was synthesized and characterised physico-chemically. A part of the mother solution of the complex and THF yielded single crystals in a triclinic space group and are found same from the crystals obtained from another mixture of the mother solution and ethyl acetate. Single crystal XRD studies have confirmed the mononuclear complex formation and absence of any interactions between the Mn(II) centers.

Bis(thio)carbohydrazone Luminogens with AIEE and ACQ Features and Their Investigations with SARS-CoV-2.

Herein, we report two novel multidentate luminogen proligands bis(3,5-diiodosalicylidene) carbohydrazone (HL) and bis(3,5-diiodosalicylidene) thiocarbohydrazone (HL), which are suitable candidates for biomedical applications. Though the thiocarbohydrazone HL shows aggregation caused quenching (ACQ), the carbohydrazone HL exhibits stronger fluorescence due to aggregation induced emission enhancement (AIEE). Molecular docking studies of HL and HL along with four similar (thio)carbohydrazones with the active sites of SARS-CoV-2 main protease 3CL reveals that the thiocarbohydrazones, in general, are showing better propensity compared to their oxygen analogues.