Immune responses induced by intranasal imiquimod and implications for therapeutics in rhinovirus infections.

Notwithstanding the progress recently made in immunology and virology, there is yet no effective, specific treatment for the common cold. Symptomatic treatment is minimally effective. An anecdotal report of rapid clearing of the common cold of recent onset after intranasal application of imiquimod in several subjects by one of the authors, made us test the hypothesis that this treatment works through the secretion of interferon by the nasal mucosa.

Peforating calcinosis cutis presenting as milia.

Two children with unusual milia-like lesions on the pubic and groin area were found to have idiopathic perforating calcinosis cutis. The inconspicuous clinical appearance may escape detection unless a biopsy is performed.