Comparing Outcomes Between CPX-351 and Fludarabine-Based Induction in Secondary Acute Myeloid Leukemia in the Real-World Setting: The Prognostic Role of Measurable Residual Disease.

Secondary acute myeloid leukemia (s-AML) is associated with inferior outcomes with conventional chemotherapy, and fludarabine combinations (FLAG-Ida) have been tested to improve results. More recently, CPX-351 resulted superior to conventional 3 + 7 in s-AML patients. In the UK NCRI AML19 trial, AML patients were randomized to receive either FLAG-Ida or CPX-351.

Thin free-standing liquid films manipulation: device design to turn on/off gravity in flow regimes for thickness map control and for material structuring.

The manipulation and control of free-standing liquid film drainage dynamics is of paramount importance in many technological fields and related products, ranging from liquid lenses to liquid foams and 2D structures. In this context, we theoretically design and introduce a device where we can reversibly drive flow regime switch between viscous-capillary and viscous-gravity in a thin free-standing liquid film by altering its shape, allowing us to manipulate and stabilize the film thickness over time. The device, which mainly consists of a syringe pump, a pressure transducer, and a 3D-printed cylinder, is coupled with a digital holography setup to measure, in real time, the evolution of the local film thickness map, revealing characteristic features of viscous-capillary and viscous-gravity driven drainage regimes.

Bubble dynamics manipulation in polymeric foaming.

The release of pressure from a high-pressure-stable polymer/gas solution is a common method for creating gas bubbles and forming foam with a typical polyhedral cell structure. We propose a new approach to control the foaming process by pausing the bubble growth at intermediate pressure before reaching ambient pressure. This allows us to control the growth of the bubbles and investigate various physical phenomena involved in polymer foaming, such as Ostwald ripening, bubble interactions, coalescence, and different bubble growth regimes.

Investigating heavy metal concentrations in sea snakes (Elapidae: Hydrophiinae) as an outcome of oil spill exposure.

This study reports the concentration of heavy metals in the tissues of stranded sea snakes that died as a result of exposure to an oil spill on the eastern coast of Sharjah, UAE. Given the limited occurrence of stranded sea snakes observed along Sharjah's eastern coast outside this spill incident, we are using strandings collected from the nearby Arabian Gulf coast of Sharjah to compare the levels of heavy metals in sea snakes affected by the oil spill against their non-oiled counterparts. The sample comprised 14 Arabian Gulf Coral Reef Sea Snakes ), 6 Yellow-bellied Sea Snakes (), and 4 Yellow Sea Snakes ().

Liquid foaming of TPU with Methylal.

This work investigates the peculiarities of using a liquid blowing agent, namely dimethoxymethane (Methylal) to foam a thermoplastic polyurethane (TPU) in the laboratory practice of batch foaming equipment. We preliminarily measured thermodynamic properties of the polymer/gas system relevant to foaming, namely the vapor-liquid pressures at the TPU foaming temperatures. Three different paths were then explored for foaming.