Preparation of fused polycyclic vinylcyclopropanes via radical cascade reactions.

Radical cascades employing (dichloromethyl)dimethylsilyl ethers as both a point of radical initiation and termination, allow efficient entry to fused polycyclic cyclopropanes, and are also suitable for the design of other radical processes terminated by beta-elimination of chloride.

Synthesis and stereochemical confirmation of the secoiridoid glucosides nudiflosides D and A.

We describe herein an efficient access to the highly substituted cyclopentane unit present in the Nudifloside secoiridoid family via crotyl phosphonamide anion mediated conjugate addition to cyclopentenone.

PtCl2-catalyzed cycloisomerizations of 5-en-1-yn-3-ol systems.

5-En-1-yn-3-ol substrates bearing a free hydroxyl group or an acyl group are highly versatile partners for PtCl2-catalyzed cycloisomerizations. Electrophilic activation of the alkyne moiety triggers at wish a hydride or an O-acyl migration yielding at the end to regioisomeric keto derivatives. The efficient preparation of Sabina ketone, an important monoterpene precursor, has been worked out.

Two compression rods to treat unstable lesions of the pelvic ring.

The authors report 7 cases involving the surgical treatment of unstable pelvic ring fractures (Malgaigne type) using two compression bars, as described by Tile. The method was used only in cases where x-ray examination and CT scan revealed that the posterior branch of the fracture was located at the very medial aspect of the sacrum (fracture through the sacral foramina or even medial to the sacral foramina), and therefore could not be stabilized by using other devices.