Publications by authors named "E Mahla"
Article Synopsis
- The study aimed to investigate the impact of following guideline-recommended withdrawal periods of P2Y12 receptor inhibitors before on-pump coronary artery bypass grafting (CABG) on bleeding and ischemic events, noting a lack of randomized controlled trials in this area.
- Researchers analyzed data from 7 observational studies involving 4,837 patients who underwent CABG, measuring severe bleeding (BARC-4) and postoperative ischemic events.
- Results indicated that adhering to suggested withdrawal times significantly reduced the risk of severe bleeding for clopidogrel users while showing a similar trend for ticagrelor, with no significant change in 30-day mortality but a decrease in ischemic events for clopidogrel users.
Background: Major cardiac surgery related blood loss is associated with increased postoperative morbidity and mortality. Platelet dysfunction is believed to contribute to post-cardiopulmonary bypass (CPB)-induced microvascular bleeding. We hypothesised that moderately hypothermic CPB induces platelet dysfunction and that supplemental fibrinogen can restore in vitro thrombus formation.
View Article and Find Full Text PDFIntroduction: In order to reduce the risk of bleeding in patients on P2Y receptor inhibitors presenting for non-emergent coronary artery bypass grafting (CABG), current guidelines recommend a preoperative discontinuation period of at least three, five and seven days for ticagrelor, clopidogrel and prasugrel, respectively, to allow for recovery of platelet function. However, there is still substantial interinstitutional variation in preoperative management and relevant covariates of CABG-related bleeding are largely elusive so far.
Methods And Analysis: We will search PubMed (July 2013 to November 2021) and EMBASE (January 2014 to November 2021) using the following terms, MeSH terms and their synonyms: clopidogrel, prasugrel, ticagrelor, dual antiplatelet, P2Y receptor inhibitor, CABG, bleeding, haemorrhage.
We carried out a literature search in MEDLINE (PubMed) and EMBASE literature databases to provide a concise review of the role of viscoelastic testing in assessing peri-interventional platelet function and coagulation. The search identified 130 articles that were relevant for the review, covering the basic science of VHA and VHA in clinical settings including cardiac surgery, cardiology, neurology, trauma, non-cardiac surgery, obstetrics, liver disease, and COVID-19. Evidence from these articles is used to describe the important role of VHAs and platelet function testing in various peri-interventional setups.
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