Publications by authors named "E Magro"
Article Synopsis
- The study aimed to track the outcomes of patients with brain arteriovenous malformations (AVMs) who were managed conservatively, revealing key statistics on related morbidity and mortality over a 10-year period.
- Out of 1010 patients initially recruited, 434 were analyzed, with a majority having unruptured low-grade AVMs, demonstrating a 5% occurrence of serious outcomes and a higher risk in those with a history of rupture or older age.
- During the follow-up of approximately 3.2 years, 8% of patients experienced major intracranial hemorrhages, highlighting the ongoing risks associated with conservative management of AVMs.
Article Synopsis
- Hydroxyurea (HU) is the primary treatment for essential thrombocythemia (ET), but there are no clear guidelines for when to switch therapies.
- In a study of 1080 patients, 67% achieved a complete hematological response (CHR) after five years, with high-risk patients showing lower risks of arterial thrombosis if they achieved CHR.
- Patients with HU resistance or intolerance had a higher chance of developing myelofibrosis, but this did not significantly impact overall survival or thrombotic risk; CHR is linked to improved outcomes and may guide future treatment decisions.
Article Synopsis
- This study evaluates the effectiveness of non-contrast-enhanced 4D MR angiography (NCE-4D-MRA) versus contrast-enhanced 4D MR angiography (CE-4D-MRA) for diagnosing brain arteriovenous malformations (bAVMs), using digital subtraction angiography (DSA) as a reference.
- Researchers analyzed MRA results from 43 patients and found that NCE-4D-MRA had higher accuracy (0.85) and specificity (95%) than CE-4D-MRA (0.83 accuracy and 85% specificity).
- The study suggests that NCE-4D-MRA might be a safer diagnostic option for bAVMs, providing
Background: The results of a clinical trial are given in terms of primary and secondary outcomes that are obtained for each patient. Just as an instrument should provide the same result when the same object is measured repeatedly, the agreement of the adjudication of a clinical outcome between various raters is fundamental to interpret study results. The reliability of the adjudication of study endpoints determined by examination of the electronic case report forms of a pragmatic trial has not previously been tested.
View Article and Find Full Text PDF