Publications by authors named "E Maerker-Hermann"
Article Synopsis
- * The presence of CD4+CD28- T cells correlates with the severity of the disease but is not affected by the patient's age or how long they've had ankylosing spondylitis.
- * These T cells exhibit features of natural killer cells and are proinflammatory, producing IFN-gamma and perforin, and may be activated through a specific interaction with MHC class I and HLA-B27.
Genes encoded on chromosome 6 within the major histocompatibility complex region are thought to play an important role in the pathogenesis of psoriasis. A potential candidate gene is tumor necrosis factor alpha. The tumor necrosis factor alpha promoter contains several polymorphisms including two G-->A transitions at position -308 and -238, which are the most common in Caucasian populations.
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