Publications by authors named "E Mabel Coyanis"

Article Synopsis
  • MCRs (multicomponent reactions) have been utilized since their discovery in 1850 and are valued for their efficiency in creating diverse and complex organic molecules.
  • These reactions, including Ugi, Passerini, Biginelli, and Hantzsch, play a crucial role in medicinal chemistry and industrial applications while promoting sustainable practices.
  • Advantages of MCRs include atom economy, recyclable catalysts, reduced waste, and simplification of the synthesis process by combining multiple steps into one.
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We present here the design, synthesis, and photophysical properties of two novel fluorescent zinc (II) complexes, () and (), containing 4-(1-octyl-1-imidazol-4-yl)-,-diphenyl-[1,1-biphenyl]-4-yl)-4-amine and 9-(4-(1-octyl-1-imidazol-4-yl)-[1,1-biphenyl]-4-yl)-9-carbazole ligands. The newly synthesized free ligands and their zinc (II) complexes were characterized using several spectroscopic techniques; their structures were identified by single-crystal X-ray diffraction; and their photophysical properties have been studied in the context of their chemical structure. The () and () complexes showed good thermal stability at 341 °C and 365 °C, respectively.

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Blue emissions in organic light-emitting diodes (OLEDs) are essential for their application in solid-state lighting and full-colour flat panel displays. On the other hand, high-power blue emitters are still uncommon, especially those that can achieve the Commission Internationale de l'Eclairage (CIE, X, Y) coordinates of (0.14, 0.

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Reaction of benzimidazolone derivatives, or their thio- or aza-counterparts, with an isocyanide in the presence of acetone unexpectedly gave rise to novel tricyclic benzodiazepine derivatives in good yield by means of a four-component reaction incorporating two moles of acetone. Benzimidazole starting substrates bearing an electron-withdrawing group gave rise instead to dihydroquinoxaline derivatives by means of a three-component reaction. Use of deuterated acetone instead of acetone in the reactions significantly affected yield and reactivity in the four-component reaction but not in the three-component reaction.

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Two targeted sets of novel 1,5-diaryl-1-imidazole-4-carboxylic acids and carbohydrazides were designed and synthesized from their corresponding ester intermediates , which were prepared via cycloaddition of ethyl isocyanoacetate and diarylimidoyl chlorides . Evaluation of these new target scaffolds in the AlphaScreen HIV-1 IN-LEDGF/p75 inhibition assay identified seventeen compounds exceeding the pre-defined 50% inhibitory threshold at 100 µM concentration. Further evaluation of these compounds in the HIV-1 IN strand transfer assay at 100 μM showed that none of the compounds (with the exception of , , and , with marginal inhibitory percentages) were actively bound to the active site, indicating that they are selectively binding to the LEDGF/p75-binding pocket.

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