We present here the design, synthesis, and photophysical properties of two novel fluorescent zinc (II) complexes, () and (), containing 4-(1-octyl-1-imidazol-4-yl)-,-diphenyl-[1,1-biphenyl]-4-yl)-4-amine and 9-(4-(1-octyl-1-imidazol-4-yl)-[1,1-biphenyl]-4-yl)-9-carbazole ligands. The newly synthesized free ligands and their zinc (II) complexes were characterized using several spectroscopic techniques; their structures were identified by single-crystal X-ray diffraction; and their photophysical properties have been studied in the context of their chemical structure. The () and () complexes showed good thermal stability at 341 °C and 365 °C, respectively.
View Article and Find Full Text PDFBlue emissions in organic light-emitting diodes (OLEDs) are essential for their application in solid-state lighting and full-colour flat panel displays. On the other hand, high-power blue emitters are still uncommon, especially those that can achieve the Commission Internationale de l'Eclairage (CIE, X, Y) coordinates of (0.14, 0.
View Article and Find Full Text PDFReaction of benzimidazolone derivatives, or their thio- or aza-counterparts, with an isocyanide in the presence of acetone unexpectedly gave rise to novel tricyclic benzodiazepine derivatives in good yield by means of a four-component reaction incorporating two moles of acetone. Benzimidazole starting substrates bearing an electron-withdrawing group gave rise instead to dihydroquinoxaline derivatives by means of a three-component reaction. Use of deuterated acetone instead of acetone in the reactions significantly affected yield and reactivity in the four-component reaction but not in the three-component reaction.
View Article and Find Full Text PDFTwo targeted sets of novel 1,5-diaryl-1-imidazole-4-carboxylic acids and carbohydrazides were designed and synthesized from their corresponding ester intermediates , which were prepared via cycloaddition of ethyl isocyanoacetate and diarylimidoyl chlorides . Evaluation of these new target scaffolds in the AlphaScreen HIV-1 IN-LEDGF/p75 inhibition assay identified seventeen compounds exceeding the pre-defined 50% inhibitory threshold at 100 µM concentration. Further evaluation of these compounds in the HIV-1 IN strand transfer assay at 100 μM showed that none of the compounds (with the exception of , , and , with marginal inhibitory percentages) were actively bound to the active site, indicating that they are selectively binding to the LEDGF/p75-binding pocket.
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