Publications by authors named "E M van Maarseveen"
Article Synopsis
- - The study aimed to evaluate how adalimumab trough concentrations relate to treatment responses in children with Juvenile Idiopathic Arthritis (JIA).
- - Researchers analyzed clinical data and measured adalimumab levels in blood samples from 34 pediatric patients, finding that those with secondary treatment failure had significantly lower drug concentrations compared to those with primary failure or who responded well.
- - The findings indicate that measuring adalimumab trough levels could help identify JIA patients needing higher doses of the medication to ensure effective treatment.
Background: Personalizing busulfan doses to target a narrow plasma exposure has improved the efficacy and lowered the toxicity of busulfan-based conditioning regimens used in hematopoietic cell transplant. Regional regulations guide interlaboratory proficiency testing for busulfan concentration quantification and monitoring. To date, there have been no comparisons of the busulfan pharmacokinetic modeling and dose recommendation protocols used in these laboratories.
View Article and Find Full Text PDFBackground: Dried blood spots (DBSs) have gained recent popularity as a sampling method for therapeutic drug monitoring. For patients, DBS sampling has several advantages over venous blood sampling. However, technical issues primarily influenced by hematocrit levels, interfere with the implementation of this method in daily clinical practice.
View Article and Find Full Text PDFAims: Thiopurines are important for treating inflammatory bowel disease, but are often discontinued due to adverse effects. Concomitant use of allopurinol might lower the risk of these unwanted effects, but large studies in the general population are lacking. The aims of this study were to evaluate rates of hepatotoxicity, myelotoxicity, pancreas toxicity and therapy persistence in adult thiopurine users with or without allopurinol.
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