Publications by authors named "E M Wersinger"
Purpose: To evaluate the effects of HO as an oxidant on the electroretinogram (ERG) in isolated rat retina.
Methods: Retinas were isolated from rat eyes and perfused with a nutrient solution. ERGs were recorded every 3 min.
Background And Purpose: Histamine H receptors are expressed in the peripheral vestibular system, and their selective inhibition improves vertigo symptoms in rats with unilateral vestibular lesions. The effects of SENS-111, a selective oral H receptor antagonist with high affinity to both animal and human receptors, on vertigo symptoms was evaluated in a translational in vivo model of unilateral vestibular loss.
Experimental Approach: Pharmacokinetics of SENS-111 in rats was determined to aid dose selection for efficacy testing.
At the first retinal synapse, horizontal cells (HCs) contact both photoreceptor terminals and bipolar cell dendrites, modulating information transfer between these two cell types to enhance spatial contrast and mediate color opponency. The synaptic mechanisms through which these modulations occur are still debated. The initial hypothesis of a GABAergic feedback from HCs to cones has been challenged by pharmacological inconsistencies.
View Article and Find Full Text PDFAim: A Phase 1 study was performed to evaluate safety, pharmacokinetics (PK) and pharmacodynamics (PD) of the selective histamine H receptor antagonist SENS-111, an oral small molecule.
Methods: One hundred healthy subjects were randomized in a placebo-controlled, double-blind study evaluating single-ascending doses (SAD; 100-500 mg) and multiple-ascending doses (MAD; 50-150 mg day , 4 days; 200-250 mg day , 7 days). Effects of SENS-111 on nystagmus and vertigo induced by modified caloric tests were measured in the MAD studies.