Publications by authors named "E M Varga"
Cyclic ion mobility-mass spectrometry (cIM-MS) is a powerful technique for separating and identifying isomeric mixtures of compounds. When coupled with chromatography, cIM-MS creates a multidimensional separation system, with high resolving power and peak capacity. In this study, we report the cyclic ion mobility separation and high-resolution mass spectrometry identification of four regioisomers of a Sugammadex-related impurity, abbreviated as Di-OH-SGM.
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- Comprehensive next generation sequencing (NGS) is being explored for its potential in diagnosing and treating pediatric hematologic malignancies, but its effectiveness is not yet fully established.
- The study involved comprehensive genomic profiling of 28 patients at a pediatric care center, utilizing exome and RNA sequencing to analyze various genetic changes.
- Of the 18 patients who underwent both germline and somatic sequencing, 83% had cancer-related findings, with targeted therapies beneficial for some, leading to long-term remission in a few cases.
Understanding how mechanical stress affects erythropoiesis is crucial to produce transfusable erythrocytes in fluid-turbulent bioreactors. We investigated the effects of shear-stress on differentiating CD49dCD235a primary human erythroblasts (EBL) at molecular, cellular, and functional level. Shear-stress, at differentiation onset, enhanced EBL maturation and induced upregulation of genes regulating cholesterol/lipids biosynthesis, causing changes in cell lipid composition.
View Article and Find Full Text PDFThe impact of production and cooking on protein oxidation, lipid oxidation and Maillard reaction products (MRPs) generation was evaluated for firm regular tofu, tempeh, and seitan, three plant-based alternatives to meat products. Tofu showed higher content of protein-bound carbonyls (25.5 ± 5.
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