Publications by authors named "E M Sulman"
Article Synopsis
- Glioblastoma (GBM) is a severe brain cancer that can lead to toxic side effects during treatment, prompting this study to explore genetic and clinical factors associated with vascular toxicities such as thrombosis and hypertension in patients.
- A total of 591 Non-Hispanic White GBM patients were analyzed, with 62 experiencing thrombosis and 59 hypertension, revealing that hypertensive patients had improved survival rates compared to those without hypertension.
- The study found that genetic factors significantly predicted hypertension better than clinical data alone, while corticosteroid use was identified as a notable risk factor for thrombosis, suggesting a need for further research into these associations in cancer treatments.
Background And Objectives: The management of World Health Organization (WHO) grade 2 meningiomas is complicated by their diverse clinical behaviors. Stereotactic radiosurgery (SRS) can be an effective management option. Literature on SRS dose selection is limited but suggests that a higher dose is better for tumor control.
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- Glioblastoma patients typically have a poor prognosis even after standard treatments, prompting research into new combinations of therapy.
- The study evaluated the effectiveness of veliparib combined with temozolomide for glioblastoma patients with MGMT promoter hypermethylation, hoping to enhance treatment outcomes.
- Results showed a slight improvement in median overall survival for the veliparib group compared to the placebo, but the difference wasn't significant enough to meet efficacy goals, though the combination treatment was generally well tolerated.