Reinventing the evaluation wheel: COGwheel's co-designed digital innovation using the Qualtrics heat map.

The involvement of service-users, clinicians, and other health service end-users is recognised as an essential part of health and medical research. This collaborative approach can significantly contribute to methodological advancements including the development of research instruments and measures that ensure their suitability for research participants. The current paper details the co-design, development and implementation of the novel, digitised COGwheel (Co-designed Outcomes for Guests Evaluation Wheel).

Repeatability of critical thermal maximum (CT) in two freshwater ectotherms across contexts.

Critical thermal maximum (CT) is the most widely used method for quantifying acute upper thermal limits in ectotherms. CT protocol exposes animals to a consistent rate of environmental warming until they lose motor function. CT has been used to assess intraspecific variation among life stages, populations, or as a function of body size, often with the assumption that it is a durable and heritable trait at the individual level.

Leg Dominance Effects During Single- and Dual-Task Modified Balance Error Scoring System Assessment in Collegiate and High School Athletes.

Background: The modified Balance Error Scoring System (mBESS) incorporates nondominant leg stance for a ceiling effect, but that may not be the worse balancing leg. Updated recommendations call for single- and dual-task tandem gait, but limited research has explored these effects on the mBESS.

Purposes: To compare mBESS performance between dominant and nondominant legs during single and dual tasks and to determine 1-week test-retest reliability.

Evaluation of the In Vivo Efficacy of the JAK Inhibitor AZD1480 in Uterine Leiomyomas Using a Patient-derived Xenograft Murine Model.

Uterine leiomyomas are common noncancerous hormonally-dependent neoplasms comprised of uterine smooth-muscle cells and fibroblasts. Despite their significant impact on morbidity, effective non-hormonal medical treatments are lacking. In vitro studies have identified the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway as a promising target in leiomyoma cells.

Does Cement Viscosity Impact Antibiotic Elution and In Vitro Efficacy Against Common Prosthetic Joint Infection Pathogens?

Background: Polymethylmethacrylate (PMMA) antibiotic-laden bone cement (ALBC) is commonly used in total joint arthroplasty to treat and potentially prevent prosthetic joint infection (PJI). Multiple properties impact the elution characteristics of antibiotics from PMMA-based ALBC, including viscosity. What is not known is how medium-viscosity cement formulations affect antibiotic elution and how different cement products from different manufacturers compare regarding reaching the minimum inhibitory concentration (MIC) of antibiotics for common PJI-causing organisms in an in vitro setting.