[Hexamidine content of the blood plasma and cerebrospinal fluid in patients with epilepsy].

In 74 patients with different attack rates and patterns mean levels of hexamidine in the blood plasma and cerebrospinal fluid were 15.9 micrograms/ml and 7.86 micrograms/ml, respectively, the former almost twice as high as the latter.

[Concentration of benzonal in the blood of epileptic patients at different daily doses and with other anticonvulsants].

A study involving 36 epileptic patients and 8 control subjects was devoted to the optimization of antiepileptic drug therapy with the help of determining the blood levels of anticonvulsants (benzonal, phenobarbital). The daily dose of an anticonvulsant directly correlated with its blood levels. Blood levels of benzonal increased upon the additional administration to patients of hexamidine or hexamidine and diphenylhydantoin mixtures.

[Blood testosterone levels in nonpsychotic psychopath-like behavior disorders among adolescents with accelerated or delayed physical development].

The authors examined 128 male adolescents admitted to a psychiatric hospital for the psychopathlike syndrome free of psychotic manifestations which was associated with the abnormal rate of sexual development. A correlation was established between the maturation rate, plasma testosterone levels and clinical features of behavioural abnormalities. Retarded puberty was related to decreased testosterone concentrations throughout the pubertal period.

[Effect of chemical destruction of hypothalamic monoaminergic terminals on function of the adrenal cortex, thyroid gland and enterochromaffin system].

In experiments on rats the influence of noradrenergic, dopaminergic terminal destruction after 6-hydroxydopamine intraventricular injection and of serotoninergic terminal damage following 5,6-hydroxytryptamine administration on the adrenal cortex, thyroid and enterochromaffin body function was studied under basal conditions and during cold stress. As a result of noradrenergic terminal destruction basal- and cold stress-induced functional activity of the adrenal cortex and enterochromaffin body augmented. After serotoninergic terminal damage stress-induced intensification of the functional activity of the endocrine glands mentioned was blocked.

[Role of hypothalamic monoaminergic structures in regulating sympatho-adrenal system function].

The effect of pharmacological destruction of hypothalamic monoaminergic terminals on the basal and cold stress-induced secretion of neurohormones of the sympathoadrenal system (SAS) in rats was studied. The data obtained on biochemical and histochemical analysis of the hypothalamus (dopamine, noradrenaline and serotonin level, the picture of catecholaminergic terminal fluorescence) were compared with adrenaline and noradrenaline content in blood. It is assumed that function of the SAS is inhibited by hypothalamic noradrenaline and stimulated by dopamine and serotonin under cold stress.