Publications by authors named "E M Spinelli"
Background: This study aims at applying the AT(N) classification to a cohort of patients with Alzheimer’s disease (AD) and related disorders, and to investigate how many cases would be eligible for the emerging disease‐modifying treatments.
Method: We conducted a retrospective evaluation of 429 patients referred to the Memory Center of IRCCS San Raffaele Hospital in Milan. Patients underwent clinical/neuropsychological assessments, lumbar puncture, structural brain imaging, and positron emission tomography (FDG‐PET).
Background: Previous EEG studies highlighted the potential of analyzing neural oscillatory activity for differentially diagnosing Alzheimer’s disease (AD) and frontotemporal dementia (FTD). We recently studied primary progressive aphasia (PPA) variants associated with AD and FTD, revealing distinctive patterns of alterations in linear lagged connectivity (LLC) values within the default mode network (DMN) and the salience network (SN). This study utilizes the same functional MRI‐driven model for source reconstruction to investigate LLC values across typical amnestic AD and the behavioral variant of FTD (bvFTD).
View Article and Find Full Text PDFBackground: Local flaps for breast reconstruction are becoming recognized as a viable alternative to remote flaps.
Objectives: The purpose of this manuscript is to describe the anatomy and clinical outcomes using the internal mammary artery perforators and the lateral intercostal artery perforator flaps for breast reconstruction.
Methods: Twelve cadaveric specimens were injected with colored latex and dissected to demonstrate the medial perforators of the 5th intercostal space.
Article Synopsis
- Poor affect recognition is an early indicator of frontotemporal dementia (FTD), and this study used the Comprehensive Affect Testing System (CATS-A) to assess emotional dysfunction in FTD patients compared to healthy controls.
- The study involved 139 FTD patients of various subtypes and tested them alongside 116 healthy controls, measuring their Affective Recognition Quotient (ARQ) to evaluate emotional recognition accuracy.
- Results showed that the CATS-A effectively differentiated between FTD patients and healthy controls with high accuracy (AUC 0.89) and had robust internal reliability, suggesting it's a valuable clinical tool for assessing emotional dysfunction in FTD.
Article Synopsis
- The study focused on predicting the spread of pathology in frontotemporal dementia (FTD) to improve early diagnosis and intervention, utilizing the Network Diffusion Model (NDM) to analyze brain atrophy in patients.
- Researchers examined various FTD subtypes, finding four main epicenters of atrophy, with significant correlations between NDM predictions and actual longitudinal changes observed in patients over 24 months.
- Results highlighted the progression patterns of different FTD variants, with notable early involvement in specific brain regions and varying effects on atrophy depending on the subtype, particularly in semantic-variant PPA and semantic behavioral variant FTD.