[Impact of endogenous porphyrin-photosensitized exposure on peripheral lymphocytes in patients with pulmonary tuberculosis].

Peripheral lymphocytes (PL) were studied in 63 patients with pulmonary tuberculosis and 28 donors. The study revealed the elevated levels of lipid peroxidation products, altered membrane potential, and diminished PL viability in patients with pulmonary tuberculosis as compared with healthy donors. Analysis of the time dependences of cell viability and production of active tuberculosis products after endogenous porphyrin-photosensitized exposure suggests that the lymphocytes from patients with pulmonary tuberculosis are more exposed to the damaging effect of free radicals than the cells from healthy individuals.

[Testing Mycobacterium tuberculosis for drug sensitivity using different methods].

Testing 35 Mycobacteria tuberculosis strains isolated from patients for drug sensitivity on the Löwenstein-Yersen, Middlebrook 7 H11 midia and by using the polymerase chain reaction demonstrated a correlations of the results obtained by these methods. In laboratory practice, the use of all possible of guidelines for testing Mycobacteria tuberculosis for drug sensitivity.

[Detection of Mycobacterium tuberculosis by different methods].

Comparative assessment of the sensitivity of detection of Mycobacteria tuberculosis by using bacterioscopy after Ziehl-Nilsen, the cultural study on the Finn II yolk medium and Middlebrook 7H11 agar medium, and polymerase chain reaction indicated that a complex microbiological study with all available laboratory methods should be used.

[Tuberculosis and opportunistic infections].

A serological study of blood from 44 patients with acutely progressive forms of pulmonary tuberculosis revealed their rather common association with active forms of the following opportunistic infections, such as M. pneumonia, Pn. carinii, and herpes simplex virus.

[Differential diagnosis significance of measuring surfactant phospholipid levels in lung diseases].

The levels of surfactant phospholipid from bronchoalveolar lavage were measured in 70 patients with pulmonary diseases and in 10 apparently healthy individuals. The levels of surfactant phospholipid components were lower in patients with peripheral lung cancer, infiltrative tuberculosis, focal pneumonia, most significant in cancer; differential diagnostic criteria for these diseases are defined.