Publications by authors named "E M Sigurdsson"
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFImportance: Comprehensive data on the prevalence of various life stressors and their role in posttraumatic stress disorder (PTSD) among women are lacking.
Objective: To determine the prevalence of a broad range of life stressors and their association with PTSD in a large nationally representative cohort of women.
Design, Setting, And Participants: This cross-sectional analysis used data from the population-based Stress-And-Gene-Analysis, which invited women in Iceland to complete an online survey from March 1, 2018, to July 1, 2019.
Article Synopsis
- The study investigated the relationship between lithium therapy and the risk of developing stage 3 or higher chronic kidney disease among adults in Iceland, focusing on those treated for mood disorders between 2008 and 2017.
- It was a population-based cohort study that compared patients receiving lithium with a control group who had mood disorders but were not on lithium, taking into account various factors to ensure accurate results.
- The findings revealed important insights but lacked input from individuals with lived experience in the design or execution of the study, highlighting a potential gap in patient-centered research.
Mendelian Randomization studies indicate that BMI contributes to various diseases, but it's unclear if this is entirely mediated by BMI itself. This study examines whether disease risk from BMI-associated sequence variants is mediated through BMI or other mechanisms, using data from Iceland and the UK Biobank. The associations of BMI genetic risk score with diseases like fatty liver disease, knee replacement, and glucose intolerance were fully attenuated when conditioned on BMI, and largely for type 2 diabetes, heart failure, myocardial infarction, atrial fibrillation, and hip replacement.
View Article and Find Full Text PDFIntroduction: It is unclear how early neuronal deficits occur in tauopathies, if these are associated with changes in neuronal network activity, and if they can be alleviated with therapies.
Methods: To address this, we performed in vivo two-photon Ca imaging in tauopathy mice at 6 versus 12 months, compared to controls, and treated the younger animals with a tau antibody.
Results: Neuronal function was impaired at 6 months but did not deteriorate further at 12 months, presumably because cortical tau burden was comparable at these ages.